Pair Name	Epigallocatechin gallate, Vorinostat
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BIRC3	hsa330
	Up-regulation	Expression	CASP7	hsa840
In Vitro Model	MDA-MB-157	Breast carcinoma	Homo sapiens (Human)	CVCL_0618
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	HCC1806	Breast squamous cell carcinoma, acantholytic variant	Homo sapiens (Human)	CVCL_1258
Result	The compounds were able to decrease the expression of cIAP2 while increasing the expression of pro-apoptotic caspase 7. There were also changes in histone modifications, suggesting a role of epigenetic mechanisms in these changes in expression of cIAP2. These changes resulted in an increase in apoptosis. SAHA and EGCG were also capable of limiting TNBC cell migration across a fibronectin (FN) matrix.